Posts Tagged ‘DUF’

DUFs: families in need of function

April 20, 2009

Domains of Unknown Function, or DUFs, is a large set of families found in the Pfam database. Examples would be “DUF26” or “DUF282“. The DUF naming scheme was introduced by Chris Ponting, through the addition of DUF1 and DUF2 to the SMART database. These two domains were found to be widely distributed in bacterial signalling proteins. Subsequently, the functions of these domains were identified and they have since been renamed as the GGDEF and EAL domains respectively (structures shown in Figures 1 and 2). These families were added to Pfam in 1997, and little did Chris know that he was starting a trend that would see thousands of uncharacterised families being added to the domain databases. Read the rest of this entry »